{"id":4869,"date":"2024-09-29T10:24:56","date_gmt":"2024-09-29T10:24:56","guid":{"rendered":"http:\/\/new.acharyagroup.com\/?page_id=4869"},"modified":"2026-05-07T15:13:24","modified_gmt":"2026-05-07T20:43:24","slug":"oligonucleotide-materials","status":"publish","type":"page","link":"https:\/\/acharyagroup.com\/index.php\/oligonucleotide-materials\/","title":{"rendered":"Oligonucleotide Materials"},"content":{"rendered":"<div class=\"wpb-content-wrapper\">[vc_row css=&#8221;.vc_custom_1728899049538{padding-top: 80px !important;}&#8221;][vc_column width=&#8221;2\/3&#8243;][vc_column_text css=&#8221;.vc_custom_1778186544844{margin-right: 40px !important;}&#8221;]<strong>Herbert Brown Pharmaceutical and Research Laboratories. (HBPRL)<\/strong> has been into manufacturing of <strong>Oligonucleotide<\/strong> materials since last 20 years. Nobel Laureate, Dr. Herbert Brown himself inaugurated this site in 1984, hence the site name has been dedicated to him[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243; css=&#8221;.vc_custom_1728590113590{margin-top: -40px !important;}&#8221;][vc_row_inner][vc_column_inner width=&#8221;1\/2&#8243;]<style>.vcex-image.vcex_6a173ef47c43a .vcex-image-inner{max-width:150px;}<\/style><figure class=\"vcex-image vcex-module vcex_6a173ef47c43a\"><div class=\"vcex-image-inner wpex-relative wpex-inline-block\"><img width=\"477\" height=\"502\" src=\"https:\/\/acharyagroup.com\/wp-content\/uploads\/2026\/05\/14001.png\" class=\"vcex-image-img wpex-align-middle\" alt=\"\" loading=\"lazy\" decoding=\"async\" srcset=\"https:\/\/acharyagroup.com\/wp-content\/uploads\/2026\/05\/14001.png 477w, https:\/\/acharyagroup.com\/wp-content\/uploads\/2026\/05\/14001-285x300.png 285w\" sizes=\"(max-width: 477px) 100vw, 477px\" \/><\/div><\/figure>[\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;]<style>.vcex-image.vcex_6a173ef47ce36 .vcex-image-inner{max-width:150px;}<\/style><figure class=\"vcex-image vcex-module vcex_6a173ef47ce36\"><div class=\"vcex-image-inner wpex-relative wpex-inline-block\"><img width=\"796\" height=\"756\" src=\"https:\/\/acharyagroup.com\/wp-content\/uploads\/2026\/05\/45001.png\" class=\"vcex-image-img wpex-align-middle\" alt=\"\" loading=\"lazy\" decoding=\"async\" srcset=\"https:\/\/acharyagroup.com\/wp-content\/uploads\/2026\/05\/45001.png 796w, https:\/\/acharyagroup.com\/wp-content\/uploads\/2026\/05\/45001-300x285.png 300w, https:\/\/acharyagroup.com\/wp-content\/uploads\/2026\/05\/45001-768x729.png 768w\" sizes=\"(max-width: 796px) 100vw, 796px\" \/><\/div><\/figure>[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1778186600322{margin-bottom: 60px !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text css=&#8221;&#8221;]<strong>Herbert Brown Pharmaceutical and Research Laboratories. (HBPRL)<\/strong> has been into manufacturing of <strong>Oligonucleotide<\/strong> materials since last 20years. Nobel Laureate, Dr. Herbert Brown himself inaugurated this site in 1984, hence the site name has been dedicated to him<\/p>\n<p>Processes requiring extremely high accuracy and precision controls such as in loading of Solid support (polymeric beads) with oligonucleotide materials is being carried out in <strong>HBPRL<\/strong> on a regular basis.<\/p>\n<p><strong>Quality<\/strong>:\u00a0 All the manufacturing activities for Oligonucleotide materials is in GMP conditions with 21 CFR system support. Close Monitoring\u00a0 and control on the impurities as LCMS is used as a part of QC release of batches. Moisture control at ppb levels required for certain products.<\/p>\n<p><strong>Nucleosides are being exported primarily to US and European countries<\/strong><\/p>\n<p>Over the years <strong>HBPRL<\/strong> has developed expertise in making small volume high value products and thus built capabilities in the following aspects<\/p>\n<ul>\n<li>Storage and transportation at -20\u2103<\/li>\n<li>Column chromatography<\/li>\n<li>Lyophilization<\/li>\n<\/ul>\n<p><strong>Pilot scale and Plant scale reactors available<\/strong><\/p>\n<p><strong>APIs and Intermediates for domestic\/ international markets<\/strong><\/p>\n<p><strong>EHS and sustainability: HBPRL has been rated by Ecovadis<\/strong>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243; css=&#8221;.vc_custom_1728590113590{margin-top: -40px !important;}&#8221;]<style>.vcex-image.vcex_6a173ef47d427 .vcex-image-img{border-radius:var(--wpex-rounded);}<\/style><figure class=\"vcex-image vcex-module vcex_6a173ef47d427\"><div class=\"vcex-image-inner wpex-relative wpex-inline-block vc_custom_1778186441815\"><img width=\"461\" height=\"694\" src=\"https:\/\/acharyagroup.com\/wp-content\/uploads\/2024\/10\/hb-460x700-2.jpg\" class=\"vcex-image-img wpex-align-middle\" alt=\"\" loading=\"lazy\" decoding=\"async\" srcset=\"https:\/\/acharyagroup.com\/wp-content\/uploads\/2024\/10\/hb-460x700-2.jpg 461w, https:\/\/acharyagroup.com\/wp-content\/uploads\/2024\/10\/hb-460x700-2-199x300.jpg 199w\" sizes=\"(max-width: 461px) 100vw, 461px\" \/><\/div><\/figure>[\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; css=&#8221;.vc_custom_1728899135309{padding-top: 80px !important;padding-bottom: 60px !important;background-color: #f5f5f5 !important;}&#8221;][vc_column]<style>.vcex-heading.vcex_6a173ef47dc35{font-size:32px;font-weight:400;}<\/style><h3 class=\"vcex-heading vcex-heading-plain vcex-module wpex-heading wpex-text-2xl wpex-text-left vc_custom_1728899184792 vcex_6a173ef47dc35\"><span class=\"vcex-heading-inner wpex-inline-block\">Nucleosides: DNA and RNA building blocks<\/span><\/h3>[vc_column_text css=&#8221;&#8221;]<strong>Sulfur Transfer Agent for synthesis of Oligonucleotides<\/strong><\/p>\n<ul>\n<li>Bis(phenylacetyl) disulfide (PADS) <b>CAS No: 15088-78-5<\/b><\/li>\n<li>Xanthane hydride <b>CAS No: 6846-35-1<\/b><\/li>\n<\/ul>\n<p><strong>Reagents<\/strong><\/p>\n<ul>\n<li>PHOS Reagent <b>CAS No.: 102691-36-1<\/b><\/li>\n<li>Dichloroacetic acid <b>CAS No: 79-43-6<\/b><\/li>\n<\/ul>\n<p><strong>Linkers with Solid Support (Refer Images\/ Brochure)<\/strong><\/p>\n<p><strong>Protected nucleosides and its Amidites<\/strong>[\/vc_column_text]<figure class=\"vcex-image vcex-module\"><div class=\"vcex-image-inner wpex-relative wpex-inline-block vc_custom_1728899223377\"><img width=\"711\" height=\"434\" src=\"https:\/\/acharyagroup.com\/wp-content\/uploads\/2024\/10\/nucleosides.jpg\" class=\"vcex-image-img wpex-align-middle\" alt=\"\" loading=\"lazy\" decoding=\"async\" srcset=\"https:\/\/acharyagroup.com\/wp-content\/uploads\/2024\/10\/nucleosides.jpg 711w, https:\/\/acharyagroup.com\/wp-content\/uploads\/2024\/10\/nucleosides-300x183.jpg 300w\" sizes=\"(max-width: 711px) 100vw, 711px\" \/><\/div><\/figure>[\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1728899969834{margin-top: 60px !important;}&#8221;][vc_column]<style>.vcex-heading.vcex_6a173ef47e866{font-size:32px;font-weight:400;}<\/style><h3 class=\"vcex-heading vcex-heading-plain vcex-module wpex-heading wpex-text-2xl wpex-text-left vc_custom_1728899928745 vcex_6a173ef47e866\"><span class=\"vcex-heading-inner wpex-inline-block\">Product Catalogue<\/span><\/h3>[vc_column_text css=&#8221;&#8221;]<div class=\"_df_book df-lite\" id=\"df_5475\"  _slug=\"5475\" data-title=\"product-catlog\" wpoptions=\"true\" thumbtype=\"\" ><\/div><script class=\"df-shortcode-script\" nowprocket type=\"application\/javascript\">window.option_df_5475 = {\"outline\":[],\"backgroundColor\":\"#f5f5f5\",\"autoEnableOutline\":\"false\",\"autoEnableThumbnail\":\"false\",\"overwritePDFOutline\":\"false\",\"enableDownload\":\"true\",\"direction\":\"1\",\"pageSize\":\"0\",\"controlsPosition\":\"hide\",\"source\":\"http:\\\/\\\/acharyagroup.com\\\/wp-content\\\/uploads\\\/2024\\\/10\\\/Acharya-TIDES-2022-Low-Res-PDF.pdf\",\"wpOptions\":\"true\"}; if(window.DFLIP && window.DFLIP.parseBooks){window.DFLIP.parseBooks();}<\/script>[\/vc_column_text][\/vc_column][\/vc_row]\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row css=&#8221;.vc_custom_1728899049538{padding-top: 80px !important;}&#8221;][vc_column width=&#8221;2\/3&#8243;][vc_column_text css=&#8221;.vc_custom_1778186544844{margin-right: 40px !important;}&#8221;]Herbert Brown Pharmaceutical and Research Laboratories. (HBPRL) has been into manufacturing of Oligonucleotide materials since last 20 years. Nobel Laureate, Dr. Herbert Brown himself inaugurated this site in 1984, hence the site name has been dedicated to him[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243; css=&#8221;.vc_custom_1728590113590{margin-top: -40px !important;}&#8221;][vc_row_inner][vc_column_inner width=&#8221;1\/2&#8243;][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1778186600322{margin-bottom: 60px !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4869","page","type-page","status-publish","hentry","entry","no-media"],"_links":{"self":[{"href":"https:\/\/acharyagroup.com\/index.php\/wp-json\/wp\/v2\/pages\/4869"}],"collection":[{"href":"https:\/\/acharyagroup.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/acharyagroup.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/acharyagroup.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/acharyagroup.com\/index.php\/wp-json\/wp\/v2\/comments?post=4869"}],"version-history":[{"count":43,"href":"https:\/\/acharyagroup.com\/index.php\/wp-json\/wp\/v2\/pages\/4869\/revisions"}],"predecessor-version":[{"id":5580,"href":"https:\/\/acharyagroup.com\/index.php\/wp-json\/wp\/v2\/pages\/4869\/revisions\/5580"}],"wp:attachment":[{"href":"https:\/\/acharyagroup.com\/index.php\/wp-json\/wp\/v2\/media?parent=4869"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}